KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
24.55
Human Site:
S222
Identified Species:
41.54
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S222
L
K
C
L
Q
M
L
S
V
E
K
I
I
H
C
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S222
L
K
C
L
Q
M
L
S
V
E
R
I
I
H
C
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S222
L
K
C
L
Q
M
L
S
V
E
K
I
I
H
C
Dog
Lupus familis
XP_534917
565
65190
Y270
L
K
C
L
Q
M
L
Y
V
E
K
I
I
H
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
Y337
L
K
C
L
H
M
L
Y
V
E
K
I
I
H
C
Rat
Rattus norvegicus
Q4V8A3
586
65492
D293
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
H185
L
R
R
R
D
R
D
H
K
G
S
M
V
H
M
Chicken
Gallus gallus
Q5ZIU3
526
59419
N232
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
Frog
Xenopus laevis
Q2TAE3
750
84138
A269
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
H330
L
K
C
L
Q
M
L
H
K
E
K
I
I
H
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
Y316
V
K
C
L
R
L
L
Y
K
E
N
I
I
H
C
Honey Bee
Apis mellifera
XP_396369
614
68978
Y301
I
S
C
L
R
L
L
Y
R
E
K
I
I
H
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
L119
A
M
I
E
I
D
V
L
Q
K
L
V
K
S
D
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
K488
L
D
S
L
C
V
L
K
E
S
K
L
I
H
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
93.3
100
93.3
N.A.
86.6
13.3
N.A.
13.3
13.3
13.3
86.6
N.A.
60
60
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
40
N.A.
33.3
46.6
33.3
86.6
N.A.
80
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
8
0
58
0
8
0
0
0
0
0
0
0
0
0
65
% C
% Asp:
0
8
0
0
8
8
8
8
0
0
0
0
0
0
8
% D
% Glu:
0
0
15
8
0
0
0
0
8
58
22
0
0
0
0
% E
% Phe:
0
15
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
15
0
0
0
0
0
72
0
% H
% Ile:
8
0
8
0
8
0
8
0
0
0
0
58
79
8
8
% I
% Lys:
0
50
0
0
0
0
0
8
22
8
50
0
8
15
15
% K
% Leu:
58
0
0
86
22
15
72
8
15
0
8
29
0
0
0
% L
% Met:
0
8
0
0
0
43
8
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
36
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
8
8
8
15
8
0
0
8
0
8
0
0
0
0
% R
% Ser:
0
8
8
0
0
15
0
22
0
8
8
0
8
8
0
% S
% Thr:
8
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
8
8
0
36
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
29
0
15
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _